Endothelial Cell Seeding of Small Diameter Vascular Grafts
نویسندگان
چکیده
منابع مشابه
Endothelial cell seeding of polymeric vascular grafts.
Pioneers in the field of small diameter graft development sought to promote graft endothelialization and, thereby, increase patency by transplanting a varying degree of autologous endothelial cells onto vascular grafts prior to implantation. This process has become known as endothelial cell seeding. The underlying hypothesis is quite simple; that is, by promoting the establishment of the patien...
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A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures. Rat arteries were acellularized with a series of detergent solutions, recellularized by incubation with a primary culture of endothelial ce...
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OBJECTIVE To develop small-diameter vascular grafts with a microstructure similar to native matrix fibers and with chemically modified microfibers to prevent thrombosis. METHODS AND RESULTS Microfibrous vascular grafts (1-mm internal diameter) were fabricated by electrospinning, and hirudin was conjugated to the poly (L-lactic acid) microfibers through an intermediate linker of poly(ethylene ...
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This study proposes a production method capable of producing vascular grafts from fully synthetic, resorbable polymers that both meet basic minimum mechanical requirements for potential vascular grafts, and have a compliance similar to that of the intended vasculature being replaced. All of the electrospun vascular grafts in this work meet the minimum mechanical requirements for compliance, bur...
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ژورنال
عنوان ژورنال: Artificial Organs
سال: 1990
ISSN: 0160-564X,1525-1594
DOI: 10.1111/j.1525-1594.1990.tb02980.x